Quantitative Analysis of Single Particle Trajectories: Mean Maximal Excursion Method
نویسندگان
چکیده
منابع مشابه
Quantitative analysis of single particle trajectories: mean maximal excursion method.
An increasing number of experimental studies employ single particle tracking to probe the physical environment in complex systems. We here propose and discuss what we believe are new methods to analyze the time series of the particle traces, in particular, for subdiffusion phenomena. We discuss the statistical properties of mean maximal excursions (MMEs), i.e., the maximal distance covered by a...
متن کاملAnalysis and Interpretation of Superresolution Single-Particle Trajectories.
A large number (tens of thousands) of single molecular trajectories on a cell membrane can now be collected by superresolution methods. The data contains information about the diffusive motion of molecule, proteins, or receptors and here we review methods for its recovery by statistical analysis of the data. The information includes the forces, organization of the membrane, the diffusion tensor...
متن کاملAnalysis of Single Particle Trajectories: from Normal to Anomalous Diffusion∗
With modern experimental tools it is possible to track the motion of single nanoparticles in real time, even in complex environments such as biological cells. The quest is then to reliably evaluate the time series of individual trajectories. While this is straightforward for particles performing normal Brownian motion, interesting subtleties occur in the case of anomalously diffusing particles:...
متن کاملAnalysis of single particle trajectories: when things go wrong
To recover the long-time behavior and the statistics of molecular trajectories from the large number (tens of thousands) of their short fragments, obtained by super-resolution methods at the single molecule level [1, 2], data analysis based on a stochastic model of their non-equilibrium motion is required. Recently, we characterized the local biophysical properties underlying receptor motion ba...
متن کاملMean square displacement analysis of single-particle trajectories with localization error: Brownian motion in an isotropic medium.
We examine the capability of mean square displacement (MSD) analysis to extract reliable values of the diffusion coefficient D of a single particle undergoing Brownian motion in an isotropic medium in the presence of localization uncertainty. The theoretical results, supported by simulations, show that a simple unweighted least-squares fit of the MSD curve can provide the best estimate of D pro...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2010
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2009.12.4282